Weijers H G, Wiesbeck G A, Jakob F, Böning J
Department of Psychiatry and Psychotherapy, Medical Policlinic, University Hospital of Würzburg, Federal Republic of Germany.
J Neural Transm (Vienna). 2001;108(8-9):1093-105. doi: 10.1007/s007020170027.
This study investigates the relationship between personality and serotonergic reactivity in alcohol dependence. Personality characteristics were assessed according to the Temperament and Character model of Cloninger, the five-factor model of McCrae and Costa, Zuckerman's Sensation Seeking as well as Eysenck's impulsiveness/venturesomeness. Placebo-controlled prolactin response to the serotonin (5-HT) reuptake inhibitor/releaser fenfluramine served as an indicator for the reactivity of serotonergic neurotransmission. Forty abstinent alcohol-dependent men were subdivided into high and low prolactin responders according to their level of neuroendocrine response. High responders were characterized by decreased harm avoidance while their extraversion and venturesomeness scores were increased in comparison to low responders. The data demonstrates that harm avoidance on the one hand and extraversion/venturesomeness on the other are inversely correlated to serotonergic neurotransmission. These results support a specific relationship between personality traits and the serotonergic system.
本研究调查了酒精依赖中人格与血清素能反应性之间的关系。根据克隆宁格的气质和性格模型、麦克雷和科斯塔的五因素模型、朱克曼的感觉寻求以及艾森克的冲动性/冒险性来评估人格特征。对血清素（5-HT）再摄取抑制剂/释放剂芬氟拉明的安慰剂对照催乳素反应作为血清素能神经传递反应性的指标。40名戒酒的酒精依赖男性根据其神经内分泌反应水平分为高催乳素反应者和低催乳素反应者。高反应者的特点是回避伤害减少，而与低反应者相比，其外向性和冒险性得分增加。数据表明，一方面回避伤害，另一方面外向性/冒险性与血清素能神经传递呈负相关。这些结果支持了人格特质与血清素能系统之间的特定关系。
