Berggren Ulf, Eriksson Matts, Fahlke Claudia, Balldin Jan
Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Sahlgren University Hospital/Mölndal, SE-431 80 Mölndal, Sweden.
Drug Alcohol Depend. 2002 Jan 1;65(2):159-65. doi: 10.1016/s0376-8716(01)00154-5.
The relationship between years of excessive alcohol consumption and central serotonergic neurotransmission, as assessed by the prolactin (PRL) response to D-fenfluramine, was investigated in 22 male alcohol-dependent subjects. A negative correlation was obtained, that is, the longer duration of excessive alcohol consumption the lower PRL response to D-fenfluramine. It is therefore suggested that long duration of excessive alcohol consumption in alcohol-dependent subjects causes a reduction in central serotonergic neurotransmission, possibly by a toxic effect of alcohol on serotonin neurons. The relationship between depressive and anxiety symptoms during on-going drinking and the PRL response to D-fenfluramine was also investigated. No such correlations were obtained, suggesting that reduction in central serotonergic neurotransmission does not pre-dispose to the development of depressive and anxiety symptoms, at least in relation to on-going drinking in alcohol-dependent subjects.
在22名男性酒精依赖患者中，研究了过量饮酒年限与中枢5-羟色胺能神经传递（通过催乳素（PRL）对右芬氟拉明的反应来评估）之间的关系。结果发现二者呈负相关，即过量饮酒时间越长，PRL对右芬氟拉明的反应越低。因此表明，酒精依赖患者长期过量饮酒会导致中枢5-羟色胺能神经传递减少，这可能是由于酒精对5-羟色胺神经元产生毒性作用所致。同时还研究了持续饮酒期间抑郁和焦虑症状与PRL对右芬氟拉明反应之间的关系。未发现此类相关性，这表明中枢5-羟色胺能神经传递减少不会导致抑郁和焦虑症状的出现，至少与酒精依赖患者的持续饮酒无关。
