Balldin J, Berggren U, Engel J, Eriksson M
Department of Clinical Neuroscience, University of Göteborg, Sweden.
Alcohol Clin Exp Res. 1994 Aug;18(4):822-5. doi: 10.1111/j.1530-0277.1994.tb00045.x.
A fenfluramine (60-mg oral dose) challenge test was performed in 19 male heavy drinkers (mean daily consumption 88 g of pure alcohol). Twelve healthy males served as controls. The prolactin and temperature responses to fenfluramine were significantly reduced in the group of heavy drinkers. The results suggest impaired central serotonergic neurotransmission in alcoholism, possibly involving subsensitivity in various serotonin receptor subtypes.
对19名男性重度饮酒者（平均每日纯酒精摄入量88克）进行了氟苯丙胺（口服剂量60毫克）激发试验。12名健康男性作为对照。重度饮酒者组对氟苯丙胺的催乳素和体温反应明显降低。结果表明酒精中毒患者中枢5-羟色胺能神经传递受损，可能涉及多种5-羟色胺受体亚型的敏感性降低。
