Nagore E, Ramos P, Botella-Estrada R, Ramos-Níguez J A, Sanmartín O, Castejón P
Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain.
Acta Derm Venereol. 2001 Aug-Sep;81(4):291-3. doi: 10.1080/00015550152572967.
Mesotherapy is a treatment method devised for controlling pain syndromes or diseases by subcutaneous microinjections given at or around the involved areas at short intervals of time. Different adverse effects have been described due to this modality of treatment. This report describes 3 patients with cutaneous infection caused by Mycobacterium fortuitum after mesotherapy. Three women, aged 24, 27 and 44 years, presented with similar clinical features, consisting of painful nodules located at the points where mesotherapy had been applied. A smear from a skin biopsy revealed the presence of acid-fast bacilli in all 3 cases. The specimen was cultured and eventually identified as M. fortuitum. A multidrug long-term regimen (combinations of 3 drugs from the following: ciprofloxacin, cotrimoxazole, clarithromycin and amoxicillin-clavulanic acid) was needed to achieve resolution of the lesions. After 15, 25 and 26 months of follow-up, no patient relapsed. Mycobacterium fortuitum is a rapidly growing mycobacterium that can lead to cutaneous infection after minor surgical procedures when aseptic measures are not adequate. Multiple drugs for several months are usually needed to treat this disease successfully.
中胚层疗法是一种通过在受累区域或其周围短时间间隔进行皮下微注射来控制疼痛综合征或疾病的治疗方法。这种治疗方式已被描述有不同的不良反应。本报告描述了3例中胚层疗法后由偶然分枝杆菌引起皮肤感染的患者。三名年龄分别为24岁、27岁和44岁的女性，表现出相似的临床特征，即中胚层疗法注射部位出现疼痛性结节。皮肤活检涂片显示所有3例均存在抗酸杆菌。标本进行培养，最终鉴定为偶然分枝杆菌。需要一种多药长期治疗方案（从以下药物中组合3种：环丙沙星、复方新诺明、克拉霉素和阿莫西林 - 克拉维酸）来使病变消退。经过15、25和26个月的随访，无患者复发。偶然分枝杆菌是一种快速生长的分枝杆菌，当无菌措施不充分时，在小手术操作后可导致皮肤感染。通常需要多种药物治疗数月才能成功治愈这种疾病。
