Tian X, Iwatsu M, Sado K, Kanai A
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
CLAO J. 2001 Oct;27(4):216-20.
To evaluate the ability of three types of disposable contact lenses to take up and release three kinds of fluoroquinolones in vitro.
We evaluated three FDA-approved disposable soft contact lenses (1-Day Acuvue, Medalist, and 14UV) for their ability to absorb and release three kinds of fluoroquinolones. Contact lenses were presoaked in fluoroquinolones for 1, 4, and 24 hours, and the uptake was determined by measuring the concentration of fluoroquinolones in the three types of disposable soft contact lenses by high pressure liquid chromatography (HPLC). After uptake, the lenses were placed in fresh saline baths, and release rates from the lenses were determined by measuring the concentration of fluoroquinolones in the saline baths by HPLC.
The disposable soft contact lens with the highest uptake of fluoroquinolones was the 1-Day Acuvue. After presoaking, drug concentrations in the 1-Day Acuvue and Medalist were higher than their theoretical saturation concentrations (i.e., the concentration of the fluoroquinolone eye drops [0.3%]). The release rates from the 1-Day Acuvue and Medalist lenses were slower than for the 14 UV lens.
These results indicate that among the lenses tested, the most practical drug delivery system is the 1-Day Acuvue disposable soft contact lens.
评估三种一次性隐形眼镜在体外吸收和释放三种氟喹诺酮类药物的能力。
我们评估了三种经美国食品药品监督管理局（FDA）批准的一次性软性隐形眼镜（1-Day Acuvue、Medalist和14UV）吸收和释放三种氟喹诺酮类药物的能力。将隐形眼镜在氟喹诺酮类药物中预浸泡1、4和24小时，通过高压液相色谱法（HPLC）测量三种一次性软性隐形眼镜中氟喹诺酮类药物的浓度来确定摄取量。摄取后，将镜片置于新鲜盐水中，通过HPLC测量盐水中氟喹诺酮类药物的浓度来确定镜片的释放率。
氟喹诺酮类药物摄取量最高的一次性软性隐形眼镜是1-Day Acuvue。预浸泡后，1-Day Acuvue和Medalist中的药物浓度高于其理论饱和浓度（即氟喹诺酮滴眼液的浓度[0.3%]）。1-Day Acuvue和Medalist镜片的释放率比14UV镜片慢。
这些结果表明，在所测试的镜片中，最实用的药物递送系统是1-Day Acuvue一次性软性隐形眼镜。
