Lesher G A, Gunderson G G
Illinois College of Optometry, Chicago.
Optom Vis Sci. 1993 Dec;70(12):1012-8. doi: 10.1097/00006324-199312000-00004.
This in vitro study examined the ability of the available disposable soft contact lenses to absorb various ocular therapeutic agents and release them. After a 2-h or 4-h presoaking time, we measured the amount of drug released into fresh saline baths for up to 3 h. Drug levels were determined spectrophotometrically at the peak ultraviolet (UV) absorption wavelength for each drug. Ciprofloxacin hydrochloride, prednisolone sodium phosphate, and cromolyn sodium were found to be released from the disposable contacts at a rate that provided higher concentrations of drug for a longer period of time than would be expected with drops. Depending on the lens used these drugs were released continuously for a period of up to 3 h. Disposable lenses soaked in pilocarpine hydrochloride or idoxuridine released drug for 30 min or less. These data indicate that disposable contact lenses could provide an acceptable means of drug delivery for some situations and overcome drawbacks associated with the use of nondisposable hydrogel lenses.
这项体外研究考察了市售一次性软性隐形眼镜吸收各种眼部治疗药物并释放这些药物的能力。经过2小时或4小时的预浸泡时间后，我们测定了在长达3小时的时间里释放到新鲜盐水中的药物量。通过分光光度法在每种药物的紫外吸收峰值波长处测定药物水平。结果发现，盐酸环丙沙星、泼尼松龙磷酸钠和色甘酸钠从一次性隐形眼镜中的释放速率，能在比滴眼液预期更长的时间内提供更高的药物浓度。根据所使用的镜片不同，这些药物可持续释放长达3小时。浸泡在盐酸毛果芸香碱或碘苷中的一次性镜片释放药物的时间为30分钟或更短。这些数据表明，一次性隐形眼镜在某些情况下可以提供一种可接受的给药方式，并克服与使用非一次性水凝胶镜片相关的缺点。
