Kalayci D, Basci N, Kortunay S, Hasiripi H, Bozkurt A
Department of Ophthalmology, Ankara Numune Hospital, Turkey.
CLAO J. 1999 Jul;25(3):182-4.
To assess the penetration of topical ciprofloxacin by a presoaked medicated disposable soft contact lens without topical drop administration.
Disposable soft contact lenses were presoaked in 0.3% topical ciprofloxacin (Ciloxan, Alcon Laboratories, Fort Worth,TX) for 10-12 hours. Presoaked lenses were placed on the eyes of patients with senile cataracts for 3 hours in group A, 5-6 hours in group B, and 8-12 hours in group C prior to their scheduled lens extraction surgery. Aqueous humor samples were drawn by paracentesis during the operation. Ciprofloxacin concentrations were determined by high pressure liquid chromatography-fluorescence detection.
The mean ciprofloxacin concentration was 2.70 +/- 0.98 microg/mL in group A, 1.22 +/- 1.0 microg/mL in group B, and 0.5 +/- 0.2 microg/mL in group C.
Penetration of topical ciprofloxacin is enhanced through a presoaked disposable soft contact lens, and at 3 hours therapeutic levels are obtained. Significant levels of ciprofloxacin are retained through 8-12 hours. This mode of treatment may increase patient compliance compared to frequent topical drop administration, and as a consequence, assure efficient treatment of keratitis, at least for the first 3 hours.
评估预先浸泡过的含药一次性软性隐形眼镜在不使用局部滴眼液的情况下对环丙沙星的渗透情况。
将一次性软性隐形眼镜浸泡在0.3%的局部用环丙沙星（Ciloxan，爱尔康实验室，沃思堡，德克萨斯州）中10 - 12小时。在预定的晶状体摘除手术前，将预先浸泡过的隐形眼镜分别放置在老年性白内障患者的眼睛上3小时（A组）、5 - 6小时（B组）和8 - 12小时（C组）。手术期间通过前房穿刺抽取房水样本。采用高压液相色谱 - 荧光检测法测定环丙沙星浓度。
A组环丙沙星平均浓度为2.70±0.98微克/毫升，B组为1.22±1.0微克/毫升，C组为0.5±0.2微克/毫升。
通过预先浸泡的一次性软性隐形眼镜可增强局部用环丙沙星的渗透，在3小时时可达到治疗水平。在8 - 12小时内仍可保持显著的环丙沙星水平。与频繁局部滴药相比，这种治疗方式可能会提高患者的依从性，因此，至少在最初3小时可确保角膜炎的有效治疗。
