Klempnaue J, Schrem H
Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover, Germany.
Metab Brain Dis. 2001 Jun;16(1-2):21-5. doi: 10.1023/a:1011606326934.
Historically, surgical shunts have played an important role in the treatment of patients with portal hypertension associated with ascites and/or variceal esophageal bleeding. Today, in the era of liver transplantation most patients with end-stage liver disease and concomitant portal hypertension and associated problems are best treated by liver grafting. The successful introduction of transjugular intrahepatic portosystemic shunting (TIPS), performed by radiologists and gastroenterologists, provides a very effective alternative to surgical shunt procedures. One advantage of TIPS is that this procedure does not interfere with subsequent liver grafting. Today, surgical shunts have clearly lost ground to the less invasive TIPS procedure. Surgical shunts still maintain a role: as a salvage procedure in selected cases and in emergency situations. Surgical shunts are associated with a high rate of encephalopathy. In most cases selective surgical shunts should be preferred to nonselective surgical shunts. The role of partial surgical shunts versus selective surgical shunts remains to be determined. Hepatic encephalopathy is a common complication of all shunt procedures and is dependent on the shunt volume. Liver grafting is able to reverse encephalopathy because of a shunting procedure. In our institution, we prefer TIPS over surgical shunts as a bridging procedure before liver transplantation.
从历史上看,外科分流术在治疗伴有腹水和/或食管静脉曲张出血的门静脉高压患者中发挥了重要作用。如今,在肝移植时代,大多数终末期肝病合并门静脉高压及相关问题的患者最好通过肝移植进行治疗。由放射科医生和胃肠病学家实施的经颈静脉肝内门体分流术(TIPS)的成功应用,为外科分流手术提供了一种非常有效的替代方法。TIPS的一个优点是该手术不会干扰后续的肝移植。如今,外科分流术显然已输给了侵入性较小的TIPS手术。外科分流术仍有其作用:在某些特定病例和紧急情况下作为挽救性手术。外科分流术与高比例的肝性脑病相关。在大多数情况下,选择性外科分流术应优于非选择性外科分流术。部分外科分流术与选择性外科分流术的作用仍有待确定。肝性脑病是所有分流手术的常见并发症,且取决于分流的量。肝移植能够因分流手术而逆转肝性脑病。在我们机构,作为肝移植前的桥接手术,我们更倾向于TIPS而非外科分流术。