巩固突触
FERMing up the synapse.
作者信息
Shaw A S
机构信息
Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
出版信息
Immunity. 2001 Nov;15(5):683-6. doi: 10.1016/s1074-7613(01)00237-0.
The immunological synapse is characterized by the reorganization of membrane proteins at the immunological synapse. Active cytoskeletal mechanisms are involved in recruiting the TCR, accessory molecules, and the integrin LFA-1 to the contact area. Other molecules like CD43 are excluded from the contact area, but the mechanism of exclusion is unknown. Three papers in this issue of Immunity demonstrate that CD43 exclusion involves the ERM family of cytoskeletal proteins.
免疫突触的特征在于免疫突触处膜蛋白的重组。活跃的细胞骨架机制参与将T细胞受体、辅助分子和整合素淋巴细胞功能相关抗原-1招募至接触区域。其他分子如CD43被排除在接触区域之外，但其排除机制尚不清楚。本期《免疫》杂志上的三篇论文表明，CD43的排除涉及细胞骨架蛋白的ERM家族。
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