Arbusow V, Theil D, Strupp M, Mascolo A, Brandt T
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany.
Audiol Neurootol. 2001 Sep-Oct;6(5):259-62. doi: 10.1159/000046131.
Reactivation of herpes simplex virus type 1 (HSV-1) in the vestibular ganglion (VG) is the suspected cause of vestibular neuritis (VN). Recent studies reported the presence of HSV-1 DNA not only in human VGs but also in vestibular nuclei, a finding that indicates the possibility of viral migration to the human vestibular labyrinth. Distribution of HSV-1 DNA was determined in geniculate ganglia, VGs, semicircular canals, and macula organs of 21 randomly obtained human temporal bones by nested PCR. Viral DNA was detected in 48% of the labyrinths, 62% of the VGs, and 57% of the geniculate ganglia. The potential significance of this finding is twofold: (1) Inflammation in VN could also involve the labyrinth and thereby cause acute unilateral vestibular deafferentation. (2) As benign paroxysmal positional vertigo often occurs in patients who have had VN, it could also be a sequel of viral labyrinthitis.
1型单纯疱疹病毒（HSV-1）在前庭神经节（VG）中的重新激活被怀疑是前庭神经炎（VN）的病因。最近的研究报告称，HSV-1 DNA不仅存在于人类的VG中，还存在于前庭核中，这一发现表明病毒有可能迁移至人类前庭迷路。通过巢式PCR在随机获取的21块人类颞骨的膝状神经节、VG、半规管和黄斑器官中确定了HSV-1 DNA的分布。在48%的迷路、62%的VG和57%的膝状神经节中检测到了病毒DNA。这一发现的潜在意义有两个方面：（1）VN中的炎症也可能累及迷路，从而导致急性单侧前庭传入神经阻滞。（2）由于良性阵发性位置性眩晕常发生在患有VN的患者中，它也可能是病毒性迷路炎的后遗症。
