Schulz P, Arbusow V, Strupp M, Dieterich M, Rauch E, Brandt T
Department of Neurology, Klinikum Grosshadern, University of Munich, Germany.
Neurosci Lett. 1998 Aug 14;252(2):139-42. doi: 10.1016/s0304-3940(98)00573-4.
Viral reactivation in temporal ganglia is the suspected cause of Bell's palsy, vestibular neuritis and sudden hearing loss. Since the distribution of latent herpes simplex type 1 (HSV-1) in geniculate, vestibular and spiral ganglia of individual human temporal bones could have implications for the explanation of isolated as well as combined disorders of these three cranial nerves, we examined these ganglia in 18 human temporal bones of adults by nested polymerase chain reaction. In all of the temporal bones HSV-1 specific DNA was detected: 10/18 (56%) of the geniculate, 11/18 (61%) of the vestibular and 9/18 (50%) of the spiral ganglia samples were positive. All combinations of positive and negative ganglia were found in individual temporal bones at roughly equal frequencies. These data support a viral etiology of all three conditions, especially their occasional combinations.
颞神经节中的病毒再激活被怀疑是贝尔麻痹、前庭神经炎和突发性听力损失的病因。由于单纯疱疹病毒1型（HSV-1）在个体人类颞骨的膝状神经节、前庭神经节和螺旋神经节中的分布可能对解释这三条颅神经的单独或合并疾病具有重要意义，我们通过巢式聚合酶链反应对18例成人人类颞骨中的这些神经节进行了检查。在所有颞骨中均检测到HSV-1特异性DNA：膝状神经节样本中10/18（56%）呈阳性，前庭神经节样本中11/18（61%）呈阳性，螺旋神经节样本中9/18（50%）呈阳性。在个体颞骨中，阳性和阴性神经节的所有组合出现的频率大致相等。这些数据支持了这三种疾病的病毒病因，尤其是它们偶尔的合并情况。
