Hantschmann N
Arzneimittelforschung. 1975 Feb;25(2):216-22.
In the perfusion model on Wistar rats the action of a single s. c. injection of betazol (Histalog) in a dose of 50 mg/kg b. w. in dependence on various types of stomach operations was studied. The following effects were observed: 1. the vagotomy shortly before the perfusion test did not reduce the effect of betazol. 2. If the vagotomy dated back at least 4 weeks, a reduction of the stimulated maximum secretion to half of the controls was seen. 3. The combination of the vagotomy with a pyloroplasty led to a reduction of the stimulated maximum acid secretion to half the amount. Futhermore, the betazol effect was shortened considerably and was demonstrable for no more than 2 h after the injection. 4. The antrectomy without vagotomy, however, casued a retardation of the answer to betazol with a maximum of the stimulated secretion in the 4th hour after s.c. injection. The dissociation of the effect of betazol caused by vagotomy or antrectomy leads to the conclusion that betazol has a direct site of action in the parietal cell and a second one in the cholinergic stimulation of the vagal system.
在Wistar大鼠灌注模型中，研究了单次皮下注射剂量为50mg/kg体重的倍他唑（组胺甲醋）在不同类型胃部手术情况下的作用。观察到以下效应：1. 在灌注试验前不久进行迷走神经切断术，并未降低倍他唑的作用。2. 如果迷走神经切断术至少在4周前进行，则刺激后的最大分泌量降至对照组的一半。3. 迷走神经切断术与幽门成形术相结合，导致刺激后的最大胃酸分泌量降至原来的一半。此外，倍他唑的作用明显缩短，注射后不超过2小时就可检测到。4. 未进行迷走神经切断术的胃窦切除术，导致对倍他唑的反应延迟，皮下注射后第4小时刺激分泌量达到最大值。迷走神经切断术或胃窦切除术引起的倍他唑作用解离，得出结论：倍他唑在壁细胞中有直接作用位点，在迷走神经系统的胆碱能刺激中有第二个作用位点。
