Hantschmann N
Arzneimittelforschung. 1975 Jan;25(1):97-101.
In the perfusion test of the stomach of rats the stimulation of acid secretion by betazol (Histalog) after one or repeated injections was studied. The experiments yielded the following results: 1. The i.v. injection of 20 mg/kg b.w. betazol was followed by a maximun acid secretion. 2. Another infusion two hours later intensified this effect. The same acid secretion was seen after a small initial dose (5 mg/kg b.w.) half an hour before the infusion of betazol. 3. The i.v. infusion of 30 mg/kg b.w. betazol showed in the intact rat stomach a smaller acid dsecretion response than did the dose of 20 mg/kg b.w. In comparison there was a significant higher stimulation with 30 mg/kg b.w. betzaol in the rat after a distal gastrectomy (antrectomy). 4. One s.c. injection of 50 mg/kg b.w. betazol showed a significant acid response of the parietal cells with a duration of at least 7 h on a percentage comparison.
在大鼠胃灌注试验中，研究了单次或重复注射倍他唑（组胺甲磺酸盐）后对胃酸分泌的刺激作用。实验得出以下结果：1.静脉注射20毫克/千克体重的倍他唑后，胃酸分泌达到最大值。2.两小时后再次输注会增强这种效果。在输注倍他唑前半小时给予小剂量初始剂量（5毫克/千克体重）后，也出现了相同的胃酸分泌情况。3.静脉输注30毫克/千克体重的倍他唑时，完整大鼠胃中的胃酸分泌反应比20毫克/千克体重的剂量小。相比之下，在远端胃切除（胃窦切除）后的大鼠中，30毫克/千克体重的倍他唑刺激作用明显更高。4.皮下注射50毫克/千克体重的倍他唑时，壁细胞出现明显的酸反应，按百分比比较，持续时间至少为7小时。
