Filleur F, Le Bail J C, Duroux J L, Simon A, Chulia A J
UPRES EA 1085, Biomolécules et cibles cellulaires tumorales, UFR de Pharmacie, Limoges, France.
Planta Med. 2001 Nov;67(8):700-4. doi: 10.1055/s-2001-18349.
Four lignans were isolated from the petrol extract of Myristica argentea mace (Myristicaceae) and their structures were elucidated by means of NMR and mass spectrometry. Although they have been previously described, NMR data are only available for threo-austrobailignan-5, which has been isolated only once, and is incomplete. Three of them, erythro-austrobailignan-6, meso-dihydroguaiaretic acid and nectandrin-B, exert an antiproliferative effect on MCF-7 cells as well as antioxidant activity on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, but not the threo-austrobailignan-5. Nectandrin-B also possesses anti-17beta-hydroxysteroid dehydrogenase and anti-aromatase activities.
从银叶肉豆蔻（肉豆蔻科）的石油醚提取物中分离出四种木脂素，并通过核磁共振（NMR）和质谱对其结构进行了阐明。尽管它们此前已有描述，但NMR数据仅适用于苏式-澳州白藜芦醇-5，该化合物仅被分离过一次，且数据不完整。其中三种，即赤式-澳州白藜芦醇-6、内消旋二氢愈创木酸和南烛木脂素-B，对MCF-7细胞具有抗增殖作用，对1,1-二苯基-2-苦基肼（DPPH）自由基具有抗氧化活性，但苏式-澳州白藜芦醇-5则没有。南烛木脂素-B还具有抗17β-羟基类固醇脱氢酶和抗芳香化酶活性。
