人细胞色素 P450 酶 5-51 作为药物和天然及环境化合物的靶点：机制、诱导和抑制-毒副作用和益处。
Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits.
机构信息
a Independent Scientist , Zagreb , Croatia.
b Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , TN , USA.
出版信息
Drug Metab Rev. 2018 Aug;50(3):256-342. doi: 10.1080/03602532.2018.1483401.
Abstract
Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic chemicals. They have also been of interest due to their very critical roles in the biosynthesis and metabolism of steroids, vitamins, and certain eicosanoids. This review covers the 22 (of the total of 57) human P450s in Families 5-51 and their substrate selectivity. Furthermore, included is information and references regarding inducibility, inhibition, and (in some cases) stimulation by chemicals. We update and discuss important aspects of each of these 22 P450s and questions that remain open.
摘要
细胞色素 P450（P450，CYP）酶由于其在药物、农药、前致癌物质和其他异源化学物质的代谢中的作用而长期受到关注。它们也因其在甾体、维生素和某些类二十烷酸的生物合成和代谢中的非常关键作用而受到关注。本综述涵盖了家族 5-51 中的 22 种（共 57 种）人 P450 及其底物选择性。此外，还包括关于化学物质诱导、抑制和（在某些情况下）刺激的信息和参考文献。我们更新并讨论了这 22 种 P450 中的每一种的重要方面以及仍然存在的问题。
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