Braca A, Cioffi G, Morelli I, Venturella F, Pizza C, De Tommasi N
Dipartimento di Chimica Bioorganica e Biofarmacia, Pisa, Italy.
Planta Med. 2001 Nov;67(8):774-6. doi: 10.1055/s-2001-18362.
Two new sesquiterpene lactones: 8alpha-(4'-acetoxymethacryloyloxy)-3alpha,9beta-dihydroxy-1(10)E,4Z,11(13)-germacratrien-12,6alpha-olide (1) and 8alpha-(2'E)-(2'-acetoxymethyl-2'-butenoyloxy)-3alpha,9beta-dihydroxy-1(10)E,4Z,11(13)-germacratrien-12,6alphaolide (2), together with the known zoapatanolide A were isolated from the aerial parts of Montanoa tomentosa Cerv. in La Llave et Lex ssp. microcephala (Sch. Bip. In K. Koch) V.A. Funk (Asteraceae). The structures of all compounds were established on the basis of 1D, 2D NMR, and EIMS analysis.
从蒙大拿绒毛菊(Montanoa tomentosa Cerv.)拉腊韦亚种小头蒙大拿绒毛菊(La Llave et Lex ssp. microcephala (Sch. Bip. In K. Koch) V.A. Funk)(菊科)的地上部分分离得到了两种新的倍半萜内酯:8α-(4'-乙酰氧基甲基丙烯酰氧基)-3α,9β-二羟基-1(10)E,4Z,11(13)-吉马三烯-12,6α-内酯(1)和8α-(2'E)-(2'-乙酰氧基甲基-2'-丁烯酰氧基)-3α,9β-二羟基-1(10)E,4Z,11(13)-吉马三烯-12,6α-内酯(2),以及已知的佐帕他诺内酯A。所有化合物的结构均通过一维、二维核磁共振和电子轰击质谱分析确定。