Topcu G, Cordell G A, Farnsworth N R, Fong H H
Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
J Pharm Sci. 1988 Jun;77(6):553-6. doi: 10.1002/jps.2600770620.
Investigation of the leaves of Montanoa tomentosa Cerv. ssp. microcephala (Sch.-Bip.) Funk (Compositae) resulted in the isolation of three novel guaianolide sesquiterpenes, montacephalin (1), tomencephalin (2), and 5-hydroxytomencephalin (3), which were shown to be cytotoxic (P-388). The structures of these sesquiterpenes were elucidated through analysis of their spectroscopic characteristics, and complete proton and carbon-13 assignments were made for the new compounds. Also isolated were the known terpenes, beta-amyrin, beta-amyrin acetate, stigmasterol, stigmasterol-3 beta-D-glucoside, (-)-kaur-16-en-19-oic acid, and monoginoic acid.
对绒毛蒙塔诺草（Montanoa tomentosa Cerv.）亚种小头蒙塔诺草（Montanoa tomentosa Cerv. ssp. microcephala (Sch.-Bip.) Funk）（菊科）的叶子进行研究，从中分离出三种新型愈创木烷型倍半萜内酯，即蒙小头素（1）、托小头素（2）和5-羟基托小头素（3），这些化合物显示出细胞毒性（对P - 388细胞）。通过对其光谱特征的分析阐明了这些倍半萜的结构，并对新化合物进行了完整的质子和碳-13归属。还分离出了已知的萜类化合物，如β-香树脂醇、β-香树脂醇乙酸酯、豆甾醇、豆甾醇-3β-D-葡萄糖苷、（-）-贝壳杉-16-烯-19-酸和莫诺吉诺酸。
