Hanif R, Sattar A, Qayum I
Department of Biochemistry, Ayub Medical College, Abbottabad.
J Ayub Med Coll Abbottabad. 2001 Apr-Jun;13(2):42-4.
Presence of dyslipidemia, i.e. raised Total Cholesterol (TC) and decreased High Density Lipoproteins (HDL) is an established phenomenon in type 2 diabetes mellitus. Its relationship to the fasting blood sugar (FBG) level in both diabetics and non-diabetics has yet to be established. The present study aims to show such a relationship.
150 subjects were selected and divided into two groups, one of 50 controls (non-diabetics), the other of 100 patients with type 2 diabetes mellitus. Their FBG levels were determined by enzyme oxidase method, and their TC and HDL levels were determined using a standard kit method.
FBG and TC:HDL ratios were increased in the patient group (p = < 0.001). Comparison of FBG and TC:HDL ratios revealed a highly significant rise (p = < 0.001) in the patient group. FBG with TC:HDL ratios between both groups showed a positive correlation (r = 0.554).
The results of the present study suggest an association between FBG and TC:HDL ratios, which may be a contributory factor to the increased prevalence of coronary artery disease in patients with type 2 diabetes mellitus.
血脂异常，即总胆固醇（TC）升高和高密度脂蛋白（HDL）降低，是2型糖尿病中已确立的现象。其与糖尿病患者和非糖尿病患者空腹血糖（FBG）水平的关系尚未明确。本研究旨在揭示这种关系。
选取150名受试者，分为两组，一组为50名对照组（非糖尿病患者），另一组为100名2型糖尿病患者。采用酶氧化酶法测定其空腹血糖水平，使用标准试剂盒方法测定其总胆固醇和高密度脂蛋白水平。
患者组的空腹血糖和总胆固醇：高密度脂蛋白比值升高（p = < 0.001）。空腹血糖和总胆固醇：高密度脂蛋白比值的比较显示患者组有极显著升高（p = < 0.001）。两组之间空腹血糖与总胆固醇：高密度脂蛋白比值呈正相关（r = 0.554）。
本研究结果提示空腹血糖与总胆固醇：高密度脂蛋白比值之间存在关联，这可能是2型糖尿病患者冠状动脉疾病患病率增加的一个促成因素。
