Afrasyap Lale, Oztürk Güler
Department of Biochemistry, Faculty of Health, Mugla University, Mugla, Turkey.
Vascul Pharmacol. 2004 Apr;41(3):91-6. doi: 10.1016/j.vph.2004.07.002.
Although the interaction between Hcy, NO(2)(-) and vascular disease has been extensively studied, there are no data verifying their ratios to HDL-C in coronary artery disease (CAD). We examined whether Hcy/HDL-C and NO(2)(-)/HDL-C ratios correlated with the degree of stenosis in CAD. Also, TC/HDL-C and LDL-C/HDL-C ratios were evaluated in the same individuals. Seventy subjects were divided into three groups according to coronary angiography findings: >50% stenosis (n=35, years: 50.9+/-3.4; Group 1), 5-50% stenosis (n=20, years: 50.6+/-3.8; Group 2), <5% narrowing (n=15, years: 49.0+/-3.2; control group). Hcy/HDL-C, NO(2)(-)/HDL-C, TC/HDL-C and LDL-C/HDL-C were statistically higher in both Group 1 patients (p=0.001, for all ratios) and Group 2 patients (p=0.001, p=0.001, p=0.03, 0.041, respectively) with respect to controls. The values were correlated with the degree of stenosis in the different significance levels (r=0.496, p=0.001; r=0.384, p=0.004; r=0.334, p=0.012; r=0.321, p=0.016, respectively). In patients with >50% stenosis, NO(2)(-)/HDL-C was only shown to change significantly in relation to obstructive artery number (p=0.026) and also showed a positive correlation (r=0.379, p=0.032). In conclusion, Hcy/HDL-C and NO(2)(-)/HDL-C appear to be more indicative than TC/HDL-C and LDL-C/HDL-C in the evaluation of CAD patients regarding the degree of stenosis. However, only NO(2)(-)/HDL evaluation seems to be a reliable indicator in the patients with heavy stenosis of CAD. Further studies are needed to confirm the results of present study.
尽管同型半胱氨酸（Hcy）、亚硝酸根离子（NO₂⁻）与血管疾病之间的相互作用已得到广泛研究，但尚无数据证实它们在冠状动脉疾病（CAD）中与高密度脂蛋白胆固醇（HDL-C）的比值关系。我们研究了Hcy/HDL-C和NO₂⁻/HDL-C比值是否与CAD的狭窄程度相关。此外，还对同一批个体的总胆固醇（TC）/HDL-C和低密度脂蛋白胆固醇（LDL-C）/HDL-C比值进行了评估。根据冠状动脉造影结果，70名受试者被分为三组：狭窄程度>50%（n = 35，年龄：50.9±3.4；第1组）、狭窄程度5%-50%（n = 20，年龄：50.6±3.8；第2组）、狭窄程度<5%（n = 15，年龄：49.0±3.2；对照组）。与对照组相比，第1组患者（所有比值p = 0.001）和第2组患者（分别为p = 0.001、p = 0.001、p = 0.03、0.041）的Hcy/HDL-C、NO₂⁻/HDL-C、TC/HDL-C和LDL-C/HDL-C在统计学上均更高。这些值在不同显著性水平下与狭窄程度相关（分别为r = 0.496，p = 0.001；r = 0.384，p = 0.004；r = 0.334，p = 0.012；r = 0.321，p = 0.016）。在狭窄程度>50%的患者中，仅显示NO₂⁻/HDL-C与阻塞动脉数量有关且有显著变化（p = 0.026），并且呈正相关（r = 0.379，p = 0.032）。总之，在评估CAD患者的狭窄程度方面，Hcy/HDL-C和NO₂⁻/HDL-C似乎比TC/HDL-C和LDL-C/HDL-C更具指示性。然而，只有NO₂⁻/HDL评估似乎是CAD严重狭窄患者的可靠指标。需要进一步研究来证实本研究结果。
