Brotto L A, Gorzalka B B, LaMarre A K
Department of Psychology, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4.
Neuroreport. 2001 Nov 16;12(16):3465-9. doi: 10.1097/00001756-200111160-00018.
The effects of chronic mild stress (CMS) on both sexual behaviour and wet dog shakes (WDS), a serotonergic type 2A (5-HT2A) receptor-mediated behaviour, were explored in the male rat. In addition, the possible attenuation of these effects by chronic treatment with melatonin, a putative 5-HT2A antagonist, was examined. The CMS procedure resulted in a significant increase in WDS and an overall decrease in all aspects of sexual behaviour. Concurrent melatonin administration attenuated the CMS-induced effects on sexual behaviour, but not the effects on either spontaneous WDS or WDS in response to the 5-HT2A agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, suggesting a mechanism of action other than exclusive 5-HT2A antagonism. These results are the first to demonstrate that melatonin significantly protects against the detrimental effects of a chronic stressor on sexual behaviour.
在雄性大鼠中，研究了慢性轻度应激（CMS）对性行为和湿狗抖毛（WDS，一种5-羟色胺2A型（5-HT2A）受体介导的行为）的影响。此外，还研究了褪黑素（一种假定的5-HT2A拮抗剂）长期治疗对这些影响的可能减弱作用。CMS程序导致WDS显著增加，性行为各方面总体下降。同时给予褪黑素可减弱CMS对性行为的影响，但对自发WDS或对5-HT2A激动剂1-(2,5-二甲氧基-4-碘苯基)-2-氨基丙烷的反应性WDS无影响，提示其作用机制并非单纯的5-HT2A拮抗作用。这些结果首次表明，褪黑素能显著保护性行为免受慢性应激源的有害影响。
