Gorzalka B B, Brotto L A, Hong J J
Department of Psychology, The University of British Columbia, Vancouver, Canada.
Physiol Behav. 1999 Sep;67(3):439-42. doi: 10.1016/s0031-9384(99)00096-7.
The effects of chronic corticosterone treatment on sexual behavior and on wet-dog shakes (WDS), a serotonergic type 2A (5-HT2A) receptor-mediated behavior, were explored in the male rat. In addition, the effects of acute melatonin treatment, both alone and in combination with corticosterone, were investigated. Chronic injections of corticosterone resulted in an overall decrease in consummatory measures of sexual behavior, and an increase in WDS. Furthermore, although an acute injection of melatonin alone had no effect on any recorded behavior, it attenuated the effects of corticosterone on sexual behavior and WDS. The data suggest that in the context of 5-HT2A receptor-mediated behaviors, melatonin has possible implications as a 5-HT2A antagonist.
在雄性大鼠中探究了长期给予皮质酮对性行为以及湿狗摇身行为（WDS，一种5-羟色胺2A型（5-HT2A）受体介导的行为）的影响。此外，还研究了单独给予褪黑素以及褪黑素与皮质酮联合使用时的急性给药效果。长期注射皮质酮导致性行为的完成指标总体下降，且WDS增加。此外，尽管单独急性注射褪黑素对任何记录的行为均无影响，但它减弱了皮质酮对性行为和WDS的影响。数据表明，在5-HT2A受体介导的行为背景下，褪黑素可能作为一种5-HT2A拮抗剂发挥作用。
