Gorzalka B B, Hanson L A
Department of Psychology, The University of British Columbia, Vancouver, Canada.
Behav Brain Res. 1998 Dec;97(1-2):143-51. doi: 10.1016/s0166-4328(98)00035-7.
The potential involvement of adrenal steroids in the regulation of 'wet dog shakes' (WDS) and sexual behavior was investigated in male rats treated or not with the serotonergic type 2A (5-HT2A) agonist DOI (5-HT2A receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane). In Experiment 1, the frequency of both spontaneous and DOI-induced WDS were compared in adrenalectomized and sham-adrenalectomized rats. Adrenalectomy significantly reduced the frequency of DOI-induced WDS. In Experiment 2, adrenalectomized and sham-adrenalectomized rats received either corticosterone or oil chronically and were again scored for WDS behavior. Corticosterone effectively blocked the adrenalectomy-induced reduction of WDS in the DOI treatment condition. In Experiment 3, intact male rats were chronically administered either corticosterone or oil treatment. Animals were then compared on measures of both spontaneous and DOI-induced WDS and sexual behavior. Corticosterone significantly increased WDS and inhibited sexual behavior in both the spontaneous and DOI treatment conditions. These results suggest that the adrenal steroid corticosterone is important in the regulation of WDS and sexual behavior in the male rat and that this regulation may be mediated by activity at 5-HT2A receptors.
在接受或未接受血清素能2A（5-HT2A）激动剂DOI（5-HT2A受体激动剂1-(2,5-二甲氧基-4-碘苯基)-2-氨基丙烷）治疗的雄性大鼠中，研究了肾上腺类固醇在“湿狗抖毛”（WDS）调节和性行为中的潜在作用。在实验1中，比较了肾上腺切除大鼠和假肾上腺切除大鼠自发和DOI诱导的WDS频率。肾上腺切除术显著降低了DOI诱导的WDS频率。在实验2中，肾上腺切除大鼠和假肾上腺切除大鼠长期接受皮质酮或油剂处理，并再次对WDS行为进行评分。在DOI处理条件下，皮质酮有效地阻止了肾上腺切除诱导的WDS减少。在实验3中，对完整的雄性大鼠长期给予皮质酮或油剂处理。然后比较动物自发和DOI诱导的WDS以及性行为的指标。在自发和DOI处理条件下，皮质酮均显著增加WDS并抑制性行为。这些结果表明，肾上腺类固醇皮质酮在雄性大鼠WDS和性行为的调节中起重要作用，并且这种调节可能由5-HT2A受体的活性介导。
