Avasarala J R, Cross A H, Trotter J L
Department of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S Euclid Ave, St Louis, MO 63017, USA.
Arch Neurol. 2001 Dec;58(12):2044-5. doi: 10.1001/archneur.58.12.2044.
The natural course of disease in multiple sclerosis varies. Multiple sclerosis that is clinically apparent but causes minimal disability over time has been labeled benign multiple sclerosis. The ability to predict the subsequent clinical course of multiple sclerosis on the basis of clinical and other supportive data at presentation would be invaluable. In this article we report our findings based on a retrospective analysis of 1800 patients diagnosed as having multiple sclerosis, of which 44 patients met our inclusion criteria. There was a suggestion that a low or absent number of oligoclonal bands in the cerebrospinal fluid at the time of diagnosis predicts a better prognosis. However, quantification of oligoclonal bands in cerebrospinal fluid remains an insensitive prognostic indicator and must not be used to influence decisions regarding therapeutic options.
多发性硬化症的自然病程各不相同。临床上明显但随着时间推移导致最小残疾的多发性硬化症被称为良性多发性硬化症。根据发病时的临床及其他支持性数据预测多发性硬化症后续临床病程的能力将非常宝贵。在本文中，我们报告了基于对1800例被诊断为患有多发性硬化症的患者进行回顾性分析的结果，其中44例患者符合我们的纳入标准。有迹象表明，诊断时脑脊液中寡克隆带数量低或不存在预示着较好的预后。然而，脑脊液中寡克隆带的定量仍是一种不敏感的预后指标，绝不能用于影响有关治疗选择的决策。
