经典钙黏蛋白的结构与功能。
Structure and functions of classical cadherins.
作者信息
Ivanov D B, Philippova M P, Tkachuk V A
机构信息
Laboratory of Molecular Endocrinology, Institute of Experimental Cardiology, Russian Cardiology Research and Production Association, Ministry of Public Health of the Russian Federation, Moscow, 121552, Russia.
出版信息
Biochemistry (Mosc). 2001 Oct;66(10):1174-86. doi: 10.1023/a:1012445316415.
Cadherins are a family of membrane receptors that mediate calcium-dependent homophilic cell-cell adhesion. Cadherins play a key role in the regulation of organ and tissue development during embryogenesis. In adult organisms, these proteins are responsible for formation of stable cell-cell junctions and maintenance of normal tissue structure. Disruption in expression or function of cadherins may cause uncontrolled cell migration and proliferation during tumor development. This review focuses on the structure and physiological functions of classical cadherins.
钙黏蛋白是一类膜受体家族，介导钙依赖性的同嗜性细胞间黏附。钙黏蛋白在胚胎发育过程中器官和组织发育的调控中起关键作用。在成年生物体中，这些蛋白质负责形成稳定的细胞间连接并维持正常组织结构。钙黏蛋白表达或功能的破坏可能导致肿瘤发生过程中细胞不受控制的迁移和增殖。本综述重点关注经典钙黏蛋白的结构和生理功能。
Zotero 插件