来自喜马拉雅红豆杉针叶的紫杉碱

Taxines from the needles of Taxus wallichiana.

作者信息

Prasain J K, Stefanowicz P, Kiyota T, Habeichi F, Konishi Y

机构信息

Biotechnology Research Institute, National Research Council Canada, 6100 Royalmount Avenue, Montreal, Quebec, Canada H4P 2R2.

出版信息

Phytochemistry. 2001 Dec;58(8):1167-70. doi: 10.1016/s0031-9422(01)00305-3.

DOI:10.1016/s0031-9422(01)00305-3

PMID:11738401

Abstract

A taxine, 5 alpha O-(3'-dimethylamino-3'-phenylpropionyl) taxinine M (1) together with two known compounds 7-O-acetyltaxine A (2) and 2 alpha-acetoxy-2' beta-deacetylaustrospicatine (3) were isolated from the needles of the Himalayan yew, Taxus wallichiana Zucc. Their structures were elucidated on the basis of the NMR spectral data, ESI-MS/MS analysis and chemical methods. Compounds 1 and 3 showed moderate cytotoxic activity against the lung cancer cell line A549 in vitro.

摘要

从喜马拉雅红豆杉（Taxus wallichiana Zucc.）的针叶中分离出一种紫杉碱，5α-O-(3'-二甲基氨基-3'-苯基丙酰基)紫杉宁M（1）以及两种已知化合物7-O-乙酰基紫杉碱A（2）和2α-乙酰氧基-2'β-去乙酰基澳洲紫杉碱（3）。基于核磁共振光谱数据、电喷雾串联质谱分析和化学方法阐明了它们的结构。化合物1和3在体外对肺癌细胞系A549显示出中等的细胞毒性活性。