Vogel A, Dick H B, Krummenauer F
Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany.
J Cataract Refract Surg. 2001 Dec;27(12):1961-8. doi: 10.1016/s0886-3350(01)01214-7.
To evaluate the intraobserver and interobserver variability in axial length (AL), anterior chamber depth (ACD), and corneal radius measurements using an optical biometry instrument based on partial coherence interferometry (PCI).
Johannes Gutenberg University, Mainz, Germany.
In this observational case series and interobserver reliability trial, 30 healthy, emmetropic to moderately myopic eyes of 15 volunteers were evaluated. The AL, ACD, and corneal radius were measured 20 times in 10 eyes by 1 observer to evaluate the intraobserver variability. To evaluate the interobserver variability, the measurements were taken in 20 eyes by 5 different observers. Measurements were performed using the IOLMaster (Carl Zeiss) based on PCI. The data description is based on coefficients of variation and the statistical inference on reliability estimation based on analysis of variance. The main outcome measures were intraobserver and interobserver variability and reliability in AL, ACD, and corneal radii.
The intraobserver variability (SD) was +/-25.6 microm for AL, +/-33.4 microm for ACD, and +/-12.9 microm for corneal radius. The coefficients of variation were 0.1%, 0.9%, and 0.17%, respectively. The interobserver variability (SD) was +/-21.5 microm for AL, +/-29.8 microm for ACD, and +/-15.9 microm for corneal radius. The coefficients of variation were 0.09%, 0.82%, and 0.21%, respectively. The reliability was 99.9% for AL, 97.8% for ACD, and 99.8%/99.5% for corneal radius (r1/r2). The slightly reduced reliability in ACD measurement was caused by a reduced intraobserver reliability of 1 of the 5 observers (R = 0.87).
Partial coherence biometry using the IOLMaster for AL measurement was highly reliable, offering observer-independent measurement results.
使用基于部分相干干涉测量法（PCI）的光学生物测量仪，评估眼轴长度（AL）、前房深度（ACD）和角膜半径测量中的观察者内及观察者间变异性。
德国美因茨约翰内斯·古腾堡大学。
在这个观察性病例系列和观察者间可靠性试验中，对15名志愿者的30只健康、正视至中度近视的眼睛进行了评估。一名观察者对10只眼睛的AL、ACD和角膜半径进行了20次测量，以评估观察者内变异性。为评估观察者间变异性，由5名不同观察者对20只眼睛进行测量。使用基于PCI的IOLMaster（卡尔·蔡司）进行测量。数据描述基于变异系数，统计推断基于方差分析的可靠性估计。主要观察指标为AL、ACD和角膜半径的观察者内及观察者间变异性和可靠性。
观察者内变异性（标准差）AL为±25.6微米，ACD为±33.4微米，角膜半径为±12.9微米。变异系数分别为0.1%、0.9%和0.17%。观察者间变异性（标准差）AL为±21.5微米，ACD为±29.8微米，角膜半径为±15.9微米。变异系数分别为0.09%、0.82%和0.21%。AL的可靠性为99.9%，ACD为97.8%，角膜半径（r1/r2）为99.8%/99.5%。ACD测量中可靠性略有降低是由5名观察者中1名观察者的观察者内可靠性降低（R = 0.87）所致。
使用IOLMaster进行AL测量的部分相干生物测量法高度可靠，提供与观察者无关的测量结果。
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