CD100-CD72相互作用：一种免疫调节的新机制。

The CD100-CD72 interaction: a novel mechanism of immune regulation.

作者信息

Kumanogoh A, Kikutani H

机构信息

Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

出版信息

Trends Immunol. 2001 Dec;22(12):670-6. doi: 10.1016/s1471-4906(01)02087-7.

DOI:10.1016/s1471-4906(01)02087-7

PMID:11738997

Abstract

CD100 is a 150 kDa transmembrane protein that belongs to the semaphorin family. Many members of the semaphorin family are known to play crucial roles in axon guidance, acting as chemorepulsive factors during neuronal development. CD100 is the first member of the semaphorin family for which crucial roles in the immune system have been identified. Although plexin-B1 has been shown to be the receptor for CD100 in nonlymphoid tissues, CD72 functions as its receptor in lymphoid tissues. CD100 plays a nonredundant role in the immune response by a unique mechanism that involves switching off the negative signals mediated by CD72.

摘要

CD100是一种150 kDa的跨膜蛋白，属于信号素家族。已知信号素家族的许多成员在轴突导向中发挥关键作用，在神经元发育过程中充当化学排斥因子。CD100是信号素家族中首个被确定在免疫系统中发挥关键作用的成员。尽管在非淋巴组织中已证明丛状蛋白-B1是CD100的受体，但在淋巴组织中CD72充当其受体。CD100通过一种独特的机制在免疫反应中发挥非冗余作用，该机制涉及关闭由CD72介导的负信号。