CD100/Sema4D，一种参与体液免疫和细胞免疫反应调节的淋巴细胞信号素。
CD100/Sema4D, a lymphocyte semaphorin involved in the regulation of humoral and cellular immune responses.
作者信息
Suzuki Kazuhiro, Kumanogoh Atsushi, Kikutani Hitoshi
机构信息
Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Japan.
出版信息
Cytokine Growth Factor Rev. 2003 Feb;14(1):17-24. doi: 10.1016/s1359-6101(02)00073-4.
The semaphorin family consists of soluble and membrane-bound proteins that act as chemorepulsive factors in neuronal development, thereby playing a crucial role in axon guidance. Although they are expressed in a broad range of embryonic and adult tissues, their physiological role outside the nervous system remains to be determined. Recently, emerging evidence has suggested that several semaphorins function as part of the immune system. CD100/Sema4D is the first semaphorin family member for which a critical role in the immune response has been identified. CD100 is involved in several arms of the immune response, including humoral and cell-based immunity. This review will focus on our current understanding of the role of this immunoregulatory semaphorin.
信号素家族由可溶性和膜结合蛋白组成，这些蛋白在神经元发育中作为化学排斥因子起作用，从而在轴突导向中发挥关键作用。尽管它们在广泛的胚胎和成年组织中表达，但其在神经系统之外的生理作用仍有待确定。最近，新出现的证据表明，几种信号素作为免疫系统的一部分发挥作用。CD100/Sema4D是第一个被确定在免疫反应中起关键作用的信号素家族成员。CD100参与免疫反应的多个环节，包括体液免疫和细胞免疫。本综述将聚焦于我们目前对这种免疫调节信号素作用的理解。
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