Kumanogoh A, Kikutani H
Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Cell Mol Life Sci. 2004 Feb;61(3):292-300. doi: 10.1007/s00018-003-3257-7.
The semaphorin proteins were identified originally as axonal guidance factors functioning during neuronal development. In addition to this function, several semaphorins play diverse roles outside the nervous system. The class 4 semaphorin CD100/Sema4D, which utilizes plexin-B1 and CD72 as receptors, exerts important biological effects on a variety of cells, including the neuronal, epithelial and immune cells. Here, we review recent advances exploring the molecular mechanisms governing the biological functions of CD100/Sema4D.
信号素蛋白最初被鉴定为在神经元发育过程中起作用的轴突导向因子。除了这一功能外，几种信号素在神经系统之外还发挥着多种作用。利用丛状蛋白-B1和CD72作为受体的4类信号素CD100/Sema4D，对包括神经元、上皮细胞和免疫细胞在内的多种细胞发挥重要的生物学作用。在此，我们综述了探索调控CD100/Sema4D生物学功能分子机制的最新进展。
