Semaphorin4D/CD100 在免疫性疾病中的新兴作用。

The emerging roles of semaphorin4D/CD100 in immunological diseases.

机构信息

State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

出版信息

Biochem Soc Trans. 2020 Dec 18;48(6):2875-2890. doi: 10.1042/BST20200821.

DOI:10.1042/BST20200821

PMID:33258873

Abstract

In vertebrates, the semaphorin family of proteins is composed of 21 members that are divided into five subfamilies, i.e. classes 3 to 7. Semaphorins play crucial roles in regulating multiple biological processes, such as neural remodeling, tissue regeneration, cancer progression, and, especially, in immunological regulation. Semaphorin 4D (SEMA4D), also known as CD100, is an important member of the semaphorin family and was first characterized as a lymphocyte-specific marker. SEMA4D has diverse effects on immunologic processes, including immune cell proliferation, differentiation, activation, and migration, through binding to its specific membrane receptors CD72, PLXNB1, and PLXNB2. Furthermore, SEMA4D and its underlying signaling have been increasingly linked with several immunological diseases. This review focuses on the significant immunoregulatory role of SEMA4D and the associated underlying mechanisms, as well as the potential application of SEMA4D as a diagnostic marker and therapeutic target for the treatment of immunological diseases.

摘要

在脊椎动物中，蛋白神经信号素家族由 21 个成员组成，分为五个亚家族，即 3 到 7 类。神经信号素在调节多种生物过程中发挥着关键作用，如神经重塑、组织再生、癌症进展，特别是在免疫调节方面。神经信号素 4D（SEMA4D），也称为 CD100，是神经信号素家族的重要成员，最初被描述为淋巴细胞特异性标志物。SEMA4D 通过与特定的膜受体 CD72、PLXNB1 和 PLXNB2 结合，对免疫过程产生多种影响，包括免疫细胞的增殖、分化、激活和迁移。此外，SEMA4D 及其潜在信号通路与多种免疫性疾病的发生发展密切相关。本综述重点关注 SEMA4D 的重要免疫调节作用及其相关的潜在机制，以及 SEMA4D 作为免疫性疾病诊断标志物和治疗靶点的潜在应用。