Matzinger Oscar, Schneiter Philippe, Tappy Luc
Institute of Physiology, School of Medicine, University of Lausanne, Switzerland.
Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E125-31. doi: 10.1152/ajpendo.00177.2001.
Fatty acids are known to decrease insulin-mediated glucose utilization in humans, both at rest and during exercise. To evaluate the effect of endurance training in this process, we infused lipids or saline in groups of sedentary and highly trained subjects. Whole body glucose utilization and substrate oxidation were monitored during a 2.5-h hyperinsulinemic clamp. During the last 30 min, a cycling exercise was superimposed. During hyperinsulinemia at rest, whole body glucose utilization and glucose oxidation were higher in trained subjects than in sedentary subjects. Compared with the control experiments with the antilipolytic agent acipimox, lipid infusion stimulated lipid oxidation to the same extent in trained as in sedentary subjects. It reduced whole body glucose utilization by 37% in trained and by 41% in sedentary subjects. During exercise, lipid infusion increased more lipid oxidation in trained than in sedentary subjects and reduced whole body glucose utilization by 43 +/- 4% in trained and by 22 +/- 4% in sedentary subjects (P < 0.01). The present data indicate that lipid infusion has similar effects on lipid oxidation and whole body glucose utilization during hyperinsulinemia at rest in trained and sedentary subjects. During exercise, however, it increases more lipid oxidation and produces a more important reduction in glucose utilization in trained than in sedentary subjects. These results suggest that endurance training enhances the inhibitory effect of lipids on whole body glucose metabolism during exercise.
众所周知，脂肪酸会降低人体在静息状态和运动期间胰岛素介导的葡萄糖利用率。为了评估耐力训练在此过程中的作用，我们对久坐不动的受试者组和训练有素的受试者组输注脂质或生理盐水。在2.5小时的高胰岛素钳夹期间监测全身葡萄糖利用率和底物氧化情况。在最后30分钟期间，叠加进行了骑自行车运动。在静息状态的高胰岛素血症期间，训练有素的受试者的全身葡萄糖利用率和葡萄糖氧化高于久坐不动的受试者。与使用抗脂解剂阿昔莫司的对照实验相比，脂质输注在训练有素的受试者和久坐不动的受试者中刺激脂质氧化的程度相同。它使训练有素的受试者的全身葡萄糖利用率降低了37%，使久坐不动的受试者降低了41%。在运动期间，脂质输注在训练有素的受试者中比在久坐不动的受试者中增加了更多的脂质氧化，使训练有素的受试者的全身葡萄糖利用率降低了43±4%，使久坐不动的受试者降低了22±4%（P<0.01）。目前的数据表明，脂质输注对训练有素的受试者和久坐不动的受试者在静息状态的高胰岛素血症期间的脂质氧化和全身葡萄糖利用率有相似的影响。然而，在运动期间，与久坐不动的受试者相比，它在训练有素的受试者中增加了更多的脂质氧化，并使葡萄糖利用率有更显著的降低。这些结果表明，耐力训练增强了运动期间脂质对全身葡萄糖代谢的抑制作用。
