耐力训练能预防脂毒性吗？ - Suppr

Does endurance training protect from lipotoxicity?

作者信息

Roden Michael

机构信息

Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University, Düsseldorf, Germany.

出版信息

Diabetes. 2012 Oct;61(10):2397-9. doi: 10.2337/db12-0662.

DOI:10.2337/db12-0662

PMID:22997429

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3447918/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8a/3447918/0ac6ded2d150/2397fig1.jpg

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本文引用的文献

High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.

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Mechanisms for insulin resistance: common threads and missing links.

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Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans.

Diabetologia. 2012 Apr;55(4):1140-50. doi: 10.1007/s00125-011-2419-7. Epub 2012 Jan 15.

Enhanced fatty acid oxidation and FATP4 protein expression after endurance exercise training in human skeletal muscle.

PLoS One. 2012;7(1):e29391. doi: 10.1371/journal.pone.0029391. Epub 2012 Jan 3.

Executive summary: Standards of medical care in diabetes--2012.

Diabetes Care. 2012 Jan;35 Suppl 1(Suppl 1):S4-S10. doi: 10.2337/dc12-s004.

Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?

Diabetes. 2011 Oct;60(10):2588-97. doi: 10.2337/db10-1221. Epub 2011 Aug 26.

Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes.

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Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E706-13. doi: 10.1152/ajpendo.00692.2009. Epub 2009 Dec 22.

Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals.

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Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle.

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Does endurance training protect from lipotoxicity?

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