Colino J, Outschoorn I
Dept. of Pathology, Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA.
J Infect Dis. 2001 Dec 15;184(12):1538-47. doi: 10.1086/324617. Epub 2001 Dec 3.
Although purified capsular polysaccharide of Neisseria meningitidis group B (CpsB) is not immunogenic at any age, CpsB on the bacterial surface elicits antibody responses late in ontogeny. Therefore, a detailed analysis of the ontogeny of the murine anti-CpsB response to N. meningitidis could determine key parameters regarding the poor immunogenicity of CpsB. The effects of bacterial dose, hyperimmunization, age, and sex on the induction of primary and secondary anti-CpsB immunoglobulin isotype profiles were studied. It was demonstrated that the timing and repetition of immunization and of the bacterial dose have a marked differential effect on the primary induction of anti-CpsB immunoglobulin isotypes and on the ability to induce anti-CpsB antibody responses after subsequent rechallenge. It is noteworthy that the ontogeny of the response is related to the appearance of natural anti-CpsB antibodies, but this is not associated with the presence of CpsB cross-reactive antigens in the microflora.
尽管B群脑膜炎奈瑟菌的纯化荚膜多糖（CpsB）在任何年龄都没有免疫原性，但细菌表面的CpsB在个体发育后期会引发抗体反应。因此，对小鼠针对脑膜炎奈瑟菌的抗CpsB反应的个体发育进行详细分析，可以确定有关CpsB免疫原性差的关键参数。研究了细菌剂量、超免疫、年龄和性别对初次和二次抗CpsB免疫球蛋白同种型谱诱导的影响。结果表明，免疫时间、重复次数和细菌剂量对初次诱导抗CpsB免疫球蛋白同种型以及后续再次攻击后诱导抗CpsB抗体反应的能力有显著的差异影响。值得注意的是，反应的个体发育与天然抗CpsB抗体的出现有关，但这与微生物群中CpsB交叉反应抗原的存在无关。
