Eichler V D, Kreuzer H
Arzneimittelforschung. 1975 Apr;25(4):615-22.
After several oral applications of N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)-aminehydrochloride (bromhexine, Bisolvon-R) to various calves and pigs the residue behaviour was examined. In animals slaughtered immediately after the final application significant amounts of Bisolvon were found. The substance showed a greater affinity to liver and fat tissue whilst, in general, in the muscle tissue, the lungs and kidneys only very small amounts were traceable. In the liver and lungs 3 different metabolites appeared in small quantities. They were partly in conjugated and partly in free form. Within 2 days the amounts greatly decreased and after 7 days at the latest, no residues were traceable; only in the fat of both animal species and in the kidneys of the calves were small quantities of Bisolvon still to be found. Excretion by the milk following oral and parenteral application was also studied. Only traces of Bisolvon were found, which rapidly decreased. Results of the studies show that, neither at a later date of slaughtering nor immediately after the final application, the residues in the animal tissues and in the milk examined present a danger to the health of the human consumer.
对不同的小牛和猪多次口服N-环己基-N-甲基-(2-氨基-3,5-二溴苄基)胺盐酸盐（溴己新，必嗽平-R）后，对其残留行为进行了研究。在最后一次用药后立即屠宰的动物体内发现了大量的必嗽平。该物质对肝脏和脂肪组织的亲和力更强，而一般来说，在肌肉组织、肺和肾脏中只能检测到极少量的该物质。在肝脏和肺中出现了少量的3种不同代谢物。它们部分呈结合态，部分呈游离态。2天内含量大幅下降，最迟7天后就检测不到残留；只有在两种动物的脂肪中以及小牛的肾脏中仍能发现少量的必嗽平。还研究了口服和注射给药后牛奶中的排泄情况。只发现了痕量的必嗽平，且其含量迅速下降。研究结果表明，无论是在屠宰后期还是在最后一次用药后立即检测，所检测的动物组织和牛奶中的残留对人类消费者的健康均无危害。
