白细胞通过“指南针”导航：PI3Kγ及其脂质产物的作用
Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products.
作者信息
Rickert P, Weiner O D, Wang F, Bourne H R, Servant G
机构信息
Depts of Cellular and Molecular Pharmacology and Medicine and the Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0450, USA.
出版信息
Trends Cell Biol. 2000 Nov;10(11):466-73. doi: 10.1016/s0962-8924(00)01841-9.
Abstract
Morphologic polarity is necessary for the motility of mammalian cells. In leukocytes responding to a chemoattractant, this polarity is regulated by activities of small Rho guanosine triphosphatases (Rho GTPases) and the phosphoinositide 3-kinases (PI3Ks). Moreover, in neutrophils, lipid products of PI3Ks appear to regulate activation of Rho GTPases, are required for cell motility and accumulate asymmetrically to the plasma membrane at the leading edge of polarized cells. By spatially regulating Rho GTPases and organizing the leading edge of the cell, PI3Ks and their lipid products could play pivotal roles not only in establishing leukocyte polarity but also as compass molecules that tell the cell where to crawl.
摘要
形态极性对于哺乳动物细胞的运动是必需的。在对趋化因子作出反应的白细胞中，这种极性由小Rho鸟苷三磷酸酶（Rho GTPases）和磷酸肌醇3激酶（PI3Ks）的活性调节。此外，在中性粒细胞中，PI3Ks的脂质产物似乎调节Rho GTPases的激活，是细胞运动所必需的，并在极化细胞的前沿不对称地积累到质膜上。通过在空间上调节Rho GTPases并组织细胞前沿，PI3Ks及其脂质产物不仅可以在建立白细胞极性方面发挥关键作用，还可以作为引导细胞爬行方向的罗盘分子。
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