Arnfred S M, Chen A C, Eder D N, Glenthøj B Y, Hemmingsen R P
Department of Psychiatry, University Hospital of Copenhagen, Bispebjerg, Bispebjerg Bakke 23, DK-2400 NV, København, Denmark.
Psychiatry Res. 2001 Dec 15;105(1-2):79-86. doi: 10.1016/s0165-1781(01)00316-x.
Significant somatosensory evoked potential (SEP) P50 gating has previously been found in young healthy men by the use of identical paired stimuli. In this study, the exploration of the gating paradigm was extended with the addition of a mixed modality paradigm where three different pairs of identical stimuli (clicks, right median nerve electric stimulations and proprioceptive stimuli of changing load on a handheld weight) were presented over a 12-s cycle. In both modalities repeated measures analyses of variance demonstrated no effect of paradigm. This mixed-modality recording paradigm could be used in further experiments to examine gating deficits across modalities.
此前通过使用相同的配对刺激，在年轻健康男性中发现了显著的体感诱发电位（SEP）P50门控现象。在本研究中，门控范式的探索得到了扩展，增加了一种混合模式范式，即在12秒的周期内呈现三对不同的相同刺激（点击声、右侧正中神经电刺激以及手持重物上不断变化负荷的本体感觉刺激）。在这两种模式下，重复测量方差分析均未显示范式有影响。这种混合模式记录范式可用于进一步的实验，以检查跨模式的门控缺陷。
