Roberts M C, Pinsent P J
Equine Vet J. 1975 Jul;7(3):166-72. doi: 10.1111/j.2042-3306.1975.tb03259.x.
Three horses suffering from malabsorption were shown to have alimentary lymphosarcoma predominantly affecting the small intestine and the associated lymph nodes. The diffuse cellular infiltration in two of the case produced marked changes in the villous architecture reducing the available mucosal surface area, and, with lowered or barely detectable disaccharidase activities, contributed to the impairment of digestive-absorptive processes. One of the horses maintained a voracious appetite and was not diarrhoeic, but failed to gain weight, indicating differences in the production and utilisation of energy sources absorbed from the small and the large intestines. A large proportion of plasma cells in the infiltrate, and the resulting morphological changes in two of the cases bore a striking resemblance to features of alpha chain disease, an immunodeficiency disease of man, although immunological studies were not conducted on these horses.
三只患有吸收不良的马匹被证明患有主要影响小肠及相关淋巴结的消化道淋巴肉瘤。其中两例病例中的弥漫性细胞浸润导致绒毛结构发生显著变化，减少了可用的粘膜表面积，并且由于双糖酶活性降低或几乎检测不到，导致消化吸收过程受损。其中一匹马食欲旺盛且不腹泻，但体重未增加，这表明从小肠和大肠吸收的能量来源在产生和利用方面存在差异。浸润中的大部分浆细胞以及两例病例中由此产生的形态学变化与人类免疫缺陷疾病——α链病的特征极为相似，尽管未对这些马匹进行免疫学研究。
