La Perle K M, Piercy R J, Long J F, Blomme E A
The Ohio State University, Department of Veterinary Biosciences, Columbus 43210-1093, USA.
Vet Pathol. 1998 Mar;35(2):144-6. doi: 10.1177/030098589803500209.
Multisystemic, eosinophilic, epitheliotropic disease and intestinal lymphosarcoma were diagnosed in a Paso Fino mare that presented with anorexia and weight loss. The stomach, ileum, cecum, colon, pancreas, and lungs were infiltrated by large numbers of eosinophils forming prominent eosinophilic granulomas, as well as lymphocytes and plasma cells. Two jejunal masses composed of solid sheets of neoplastic lymphocytes were present. In contrast to the regions of inflammation, the infiltrates in these masses did not contain plasma cells, eosinophils, and eosinophilic granulomas. Immunohistochemically, the neoplastic lymphocytes expressed CD3 but not CD20 or kappa and lambda light chains, supporting a diagnosis of T-cell lymphosarcoma. Concurrent diagnoses of hypereosinophilic syndrome and lymphosarcoma in this horse and several humans suggest that the multisystemic eosinophilic and lymphoplasmacytic infiltrates were caused by the clonal proliferation of T-lymphocytes that secreted interleukin-5 triggering differentiation and activation of eosinophils.
一匹呈现出厌食和体重减轻症状的帕索·菲诺母马被诊断患有多系统嗜酸性上皮嗜性疾病和肠道淋巴肉瘤。胃、回肠、盲肠、结肠、胰腺和肺被大量嗜酸性粒细胞浸润，形成显著的嗜酸性肉芽肿，同时还有淋巴细胞和浆细胞。存在两个由成片的肿瘤性淋巴细胞组成的空肠肿块。与炎症区域不同，这些肿块中的浸润细胞不包含浆细胞、嗜酸性粒细胞和嗜酸性肉芽肿。免疫组织化学显示，肿瘤性淋巴细胞表达CD3，但不表达CD20以及kappa和lambda轻链，支持T细胞淋巴肉瘤的诊断。这匹马以及几例人类患者同时被诊断为高嗜酸性粒细胞综合征和淋巴肉瘤，提示多系统嗜酸性和淋巴浆细胞浸润是由分泌白细胞介素-5的T淋巴细胞克隆增殖引起的，白细胞介素-5触发了嗜酸性粒细胞的分化和激活。
