Byberg L, Smedman A, Vessby B, Lithell H
Sections of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):2086-92. doi: 10.1161/hq1201.100224.
High plasminogen activator inhibitor (PAI)-1 levels and poor dietary fat quality are potential risk factors for cardiovascular disease. The aim was to investigate the cross-sectional associations between PAI-1 activity and dietary nutrient intake, focusing on fat quality, in a population-based study of 871 men aged 70 years. The relationship between PAI-1 and the fatty acid composition in serum cholesterol esters (n=381 men) was also studied. The estimated total fat intake was positively associated with PAI-1 activity. The intake of both monounsaturated and polyunsaturated fatty acids was positively associated with PAI-1 activity, whereas the intake of saturated fatty acids was not. In serum cholesterol esters, higher proportions of palmitoleic and dihomo-gamma-linolenic acid, a lower proportion of linoleic acid, and reduced estimated Delta5-desaturase activity were associated with higher PAI-1 levels. These associations were confounded by factors representing the insulin resistance syndrome. PAI-1 activity was positively associated with gamma-linolenic and arachidonic acid, independent of potential confounders. In conclusion, this study demonstrates that dietary intake of unsaturated fatty acids is positively associated with PAI-1 activity, whereas intake of saturated fatty acids is not. The associations present between PAI-1 activity and the fatty acid proportions in serum cholesterol esters are partly influenced by metabolic syndrome-related factors.
高纤溶酶原激活物抑制剂（PAI）-1水平和不良的膳食脂肪质量是心血管疾病的潜在危险因素。本研究旨在对871名70岁男性进行基于人群的研究，探讨PAI-1活性与膳食营养素摄入量之间的横断面关联，重点关注脂肪质量。同时还研究了PAI-1与血清胆固醇酯中脂肪酸组成（n = 381名男性）之间的关系。估计的总脂肪摄入量与PAI-1活性呈正相关。单不饱和脂肪酸和多不饱和脂肪酸的摄入量均与PAI-1活性呈正相关，而饱和脂肪酸的摄入量则不然。在血清胆固醇酯中，棕榈油酸和二高-γ-亚麻酸的比例较高、亚油酸的比例较低以及估计的Δ5-去饱和酶活性降低与较高的PAI-1水平相关。这些关联受到代表胰岛素抵抗综合征的因素的混杂影响。PAI-1活性与γ-亚麻酸和花生四烯酸呈正相关，不受潜在混杂因素的影响。总之，本研究表明，不饱和脂肪酸的膳食摄入量与PAI-1活性呈正相关，而饱和脂肪酸的摄入量则不然。PAI-1活性与血清胆固醇酯中脂肪酸比例之间的关联部分受到代谢综合征相关因素的影响。
