Department of Epidemiology and Prevention, Clinical Research Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.
Nutr Res. 2012 Sep;32(9):669-675.e3. doi: 10.1016/j.nutres.2012.07.004. Epub 2012 Aug 20.
The association of fatty acid composition with insulin resistance and type 2 diabetes has been reported in Western populations, but there is limited evidence of this association among the Japanese, whose populace consume large amounts of fish. To test the hypothesis that high palmitic, palmitoleic, and dihomo-γ-linolenic acids and low levels of linoleic and n-3 fatty acids are associated with higher insulin resistance among the Japanese, the authors investigated the relationship between serum fatty acid composition and serum C-peptide concentrations in 437 Japanese employees aged 21 to 67 years who participated in a workplace health examination. Serum cholesterol ester and phospholipid fatty acid compositions were measured by gas-liquid chromatography. Desaturase activity was estimated by fatty acid product-to-precursor ratios. A multiple regression was used to assess the association between fatty acid and C-peptide concentrations. C-peptide concentrations were associated inversely with linoleic acid levels in cholesterol ester and phospholipid (P for trend = .01 and .02, respectively) and positively with stearic and palmitoleic acids in cholesterol ester (P for trend =.02 and .006, respectively) and dihomo-γ-linolenic acid in cholesterol ester and phospholipid (P for trend < .0001 for both). C-peptide concentrations were not associated with n-3 polyunsaturated fatty acids. C-peptide concentrations significantly increased as δ-9-desaturase (16:1 n-7/16:0) and δ-6-desaturase (18:3 n-6/18:2 n-6) increased (P for trend = .01 and .03, respectively) and δ-5-desaturase (20:4 n-6/20:3 n-6) decreased (P for trend = .004). In conclusion, a fatty acid pattern with high levels of serum stearic, palmitoleic, or dihomo-γ-linolenic acids; δ-9-desaturase (16:1 n-7/16:0) or δ-6-desaturase (18:3 n-6/18:2 n-6) activities; and low levels of serum linoleic acid or δ-5-desaturase (20:4 n-6/20:3 n-6) activity might be associated with higher insulin resistance in Japanese adults.
脂肪酸组成与胰岛素抵抗和 2 型糖尿病的关系在西方人群中已有报道，但在日本人中，这种关联的证据有限，因为日本人大量食用鱼类。为了验证高棕榈酸、棕榈油酸和二高-γ-亚麻酸以及低亚油酸和 n-3 脂肪酸与日本人更高的胰岛素抵抗有关的假设，作者在参加工作场所健康检查的 437 名年龄在 21 至 67 岁的日本员工中，研究了血清脂肪酸组成与血清 C 肽浓度之间的关系。血清胆固醇酯和磷脂脂肪酸组成通过气相色谱法测定。通过脂肪酸产物与前体的比值估计去饱和酶活性。多元回归用于评估脂肪酸与 C 肽浓度之间的关联。C 肽浓度与胆固醇酯和磷脂中的亚油酸水平呈负相关（趋势 P 值分别为.01 和.02），与胆固醇酯中的硬脂酸和棕榈油酸呈正相关（趋势 P 值分别为.02 和.006），与胆固醇酯和磷脂中的二高-γ-亚麻酸呈正相关（两者的趋势 P 值均<.0001）。C 肽浓度与 n-3 多不饱和脂肪酸无关。C 肽浓度随着 δ-9 去饱和酶（16:1 n-7/16:0）和 δ-6 去饱和酶（18:3 n-6/18:2 n-6）的增加而显著增加（趋势 P 值分别为.01 和.03），而 δ-5 去饱和酶（20:4 n-6/20:3 n-6）的减少（趋势 P 值为.004）。总之，血清硬脂酸、棕榈油酸或二高-γ-亚麻酸水平高，δ-9 去饱和酶（16:1 n-7/16:0）或 δ-6 去饱和酶（18:3 n-6/18:2 n-6）活性高，血清亚油酸或 δ-5 去饱和酶（20:4 n-6/20:3 n-6）活性低的脂肪酸模式可能与日本成年人更高的胰岛素抵抗有关。
Zotero 插件