de la Calle-Mustienes Elisa, Modolell Juan, Gómez-Skarmeta José Luis
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Mech Dev. 2002 Jan;110(1-2):209-11. doi: 10.1016/s0925-4773(01)00565-2.
The iroquois (iro) genes encode evolutionary conserved homeoproteins that participate in many developmental processes [reviewed in Development 128 (2001) 2847]. In Xenopus, the Iro protein Xiro1 is a repressor, required during gastrulation for neural plate formation, that downregulates Bmp4. During neurulation, Xiro1 participates in the pattering of the neuroectoderm. In this work, we report the cloning and pattern of expression of XCoREST, another gene repressed by Xiro1. During Xenopus development, XCoREST is expressed in territories in which neurogenesis takes place.
易洛魁（iro）基因编码进化保守的同源结构域蛋白，这些蛋白参与许多发育过程[见《发育》128卷（2001年）第2847页综述]。在非洲爪蟾中，Iro蛋白Xiro1是一种阻遏物，在原肠胚形成过程中对神经板形成是必需的，它能下调Bmp4。在神经胚形成过程中，Xiro1参与神经外胚层的模式形成。在这项研究中，我们报告了XCoREST（另一个受Xiro1抑制的基因）的克隆及表达模式。在非洲爪蟾发育过程中，XCoREST在发生神经发生的区域表达。
