Rosyln and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine Albert Einstein College of Medicine, Bronx, NY, USA.
Cell Cycle. 2010 Nov 15;9(22):4477-86. doi: 10.4161/cc.9.22.13973.
Complementary transcriptional and epigenetic regulatory factors (e.g., histone and chromatin modifying enzymes and non-coding RNAs) regulate genes responsible for mediating neural stem cell maintenance and lineage restriction, neuronal and glial lineage specification, and progressive stages of lineage maturation. However, an overall understanding of the mechanisms that sense and integrate developmental signals at the genomic level and control cell type-specific gene network deployment has not emerged. REST and CoREST are central players in the transcriptional and epigenetic regulatory circuitry that is responsible for modulating neural genes, and they have been implicated in establishing cell identity and function, both within the nervous system and beyond it. Herein, we discuss the emerging context-specific roles of REST and CoREST and highlight our recent studies aimed at elucidating their neural developmental cell type- and stage-specific actions. These observations support the conclusion that REST and CoREST act as master regulators of key neural cell fate decisions.
补充性转录和表观遗传调控因子（例如，组蛋白和染色质修饰酶以及非编码 RNA）调节负责介导神经干细胞维持和谱系限制、神经元和神经胶质谱系特化以及谱系成熟的渐进阶段的基因。然而，在基因组水平上感知和整合发育信号并控制细胞类型特异性基因网络部署的机制的总体理解尚未出现。REST 和 CoREST 是负责调节神经基因的转录和表观遗传调控回路中的核心参与者，它们已被牵连到细胞身份和功能的建立中，无论是在神经系统内还是之外。在此，我们讨论了 REST 和 CoREST 的新兴特定情境作用，并强调了我们最近旨在阐明它们在神经发育细胞类型和阶段特异性作用的研究。这些观察结果支持这样的结论，即 REST 和 CoREST 作为关键神经细胞命运决定的主调控因子发挥作用。
