Verin Eric, Sériès Frédéric, Locher Chrystèle, Straus Christian, Zelter Marc, Derenne Jean-Philippe, Similowski Thomas
Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié Salpetrière, 75651 Paris, France.
J Appl Physiol (1985). 2002 Jan;92(1):84-92. doi: 10.1152/jappl.2002.92.1.84.
Phrenic nerve stimulation (PNS) can assess airflow dynamics of the upper airway (UA) during wakefulness in man. Using PNS, we aimed to assess the impact of neck flexion and mouth opening in promoting UA unstability. Measurements were made during nasal breathing in seven healthy subjects (ages = 23-39 yr; one woman). Surface diaphragm electromyogram, esophageal pressure referenced to mask pressure, and flow were recorded during diaphragm twitches with neck in neutral position and mouth closed and then with neck flexion and/or mouth opening. Twitches always exhibited a flow-limited pattern. Flow-limiting driving pressure (Pd) and peak Pd were increased by neck flexion (P < 0.01) without significant change in the corresponding flows. UA resistances at these flow values were higher with the neck flexed (P < 0.05). Mouth opening alone did not exert any significant influence. We conclude that the position of the neck has a discernible impact on the flow behavior through the nonphasically active UA faced with a negative Pd.
膈神经刺激（PNS）可评估人清醒状态下上气道（UA）的气流动力学。我们利用PNS旨在评估颈部屈曲和张口对上气道不稳定的影响。对7名健康受试者（年龄23 - 39岁；1名女性）进行鼻呼吸时的测量。在颈部处于中立位且口闭合时以及随后颈部屈曲和/或张口时记录膈肌表面肌电图、相对于面罩压力的食管压力和气流。抽搐总是呈现流量受限模式。颈部屈曲使流量限制驱动压力（Pd）和峰值Pd增加（P < 0.01），而相应气流无显著变化。在这些流量值时，颈部屈曲时上气道阻力更高（P < 0.05）。单独张口未产生任何显著影响。我们得出结论，颈部位置对面对负向Pd的非相位活动上气道的气流行为有明显影响。
