Bettley F R, O'Shea J A
Br J Dermatol. 1975 May;92(5):563-8. doi: 10.1111/j.1365-2133.1975.tb03125.x.
A test dose of arsenic was given to four patients with arsenical carcinoma. Blood arsenic levels, urinary and faecal excretion were measured and compared with those of three normal control subjects. Blood levels and urinary excretion were lower in the carcinoma subjects, suggesting increased storage. Abnormally high retention of arsenic, either medicinal or environmental, may be an individual metabolic trait and may be an important factor in carcinogenesis.
对四名砷中毒性癌患者给予了一次砷测试剂量。测量了他们的血砷水平、尿砷和粪砷排泄量，并与三名正常对照受试者的进行了比较。癌症患者的血砷水平和尿砷排泄量较低，表明砷储存增加。无论是药用还是环境来源的砷，异常高的潴留量可能是一种个体代谢特征，并且可能是致癌作用中的一个重要因素。
