Reymann F, Moller R, Nielsen A
Arch Dermatol. 1978 Mar;114(3):378-81.
An attempt has been made to assess the carcinogenic effect of arsenic intake by analyzing a group of patients who were treated with arsenic for various skin diseases in the 1930s. When compared with the expected incidence of malignant internal neoplasms, based on figures obtained from the Danish Cancer Registry, a significant increase in the incidence of internal malignant neoplasms was observed in females with multiple basal cell carcinomas. A group comprising 53 patients with arsenic keratoses presented a considerable increase in the incidence of internal malignant neoplasms. However, these patients were so specifically selected that no regular statistical analysis can be made of this group. It may be said that arsenic has a carcinogenic effect even in the relatively small doses applied in dermatological therapy.
通过分析一组在20世纪30年代因各种皮肤病接受砷治疗的患者，已尝试评估砷摄入的致癌作用。与基于丹麦癌症登记处的数据得出的恶性内部肿瘤预期发病率相比，在患有多发性基底细胞癌的女性中观察到内部恶性肿瘤发病率显著增加。一组由53名患有砷角化病的患者组成，其内部恶性肿瘤发病率有相当大的增加。然而，这些患者是经过如此特殊挑选的，以至于无法对该组进行常规统计分析。可以说，即使在皮肤科治疗中应用的相对小剂量的情况下，砷也具有致癌作用。
