Mantina H, Kankasa C, Klaskala W, Brayfield B, Campbell J, Du Q, Bhat G, Kasolo F, Mitchell C, Wood C
Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68588-0666, USA.
Int J Cancer. 2001 Dec 1;94(5):749-52. doi: 10.1002/ijc.1529.
Little is presently known about the specific routes of transmission of Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8). To investigate whether this agent might be transmitted vertically from mother to infant, we conducted a study on 89 KSHV seropositive mothers and their newborn infants. Thirteen mothers (14.6%) had KSHV DNA detected in their peripheral blood mononuclear cells (PBMC). Two of 89 samples drawn at birth from infants born to KSHV seropositive mothers had KSHV DNA detectable within their PBMC. These findings suggest that KSHV can be transmitted perinatally, but infrequently. Other routes of transmission such as horizontal transmission remain the most likely means of KSHV transmission.
目前对于卡波西肉瘤相关疱疹病毒（KSHV）或人类疱疹病毒8型（HHV - 8）的具体传播途径知之甚少。为了研究该病原体是否可能从母亲垂直传播给婴儿，我们对89名KSHV血清阳性母亲及其新生儿进行了一项研究。13名母亲（14.6%）的外周血单核细胞（PBMC）中检测到KSHV DNA。在从KSHV血清阳性母亲所生婴儿出生时采集的89份样本中，有两份在其PBMC中可检测到KSHV DNA。这些发现表明KSHV可在围产期传播，但频率较低。其他传播途径，如水平传播，仍然是KSHV传播最可能的方式。
