Vela Coral M C, Fonseca N, Castañeda E, Di Fabio J L, Hollingshead S K, Briles D E
Instituto Nacional de Salud, Bogotá, Colombia.
Emerg Infect Dis. 2001 Sep-Oct;7(5):832-6. doi: 10.3201/eid0705.017510.
Pneumococcal surface protein A (PspA) elicits protection in mice against fatal bacteremia and sepsis caused by genetically diverse pneumococci and protects against carriage and lung infection. We determined the PspA families of invasive isolates of Streptococcus pneumoniae recovered from Colombian children <5 years of age. That 97.5% of Colombian isolates belong to PspA families 1 and 2 supports the hypothesis that a human PspA vaccine covering a few PspA families could be broadly effective.
肺炎球菌表面蛋白A(PspA)可使小鼠对由基因多样的肺炎球菌引起的致命菌血症和败血症产生保护作用,并预防定植和肺部感染。我们确定了从5岁以下哥伦比亚儿童中分离出的肺炎链球菌侵袭性菌株的PspA家族。97.5%的哥伦比亚菌株属于PspA家族1和2,这支持了一种假设,即涵盖少数PspA家族的人用PspA疫苗可能具有广泛的有效性。