Brandileone Maria Cristina C, Andrade Ana Lucia S S, Teles Elaine M, Zanella Rosemeire C, Yara Teresa I, Di Fabio José Luis, Hollingshead Susan K
Bacteriology Branch, Adolfo Lutz Institute (IAL), Secretary of Health of the State of São Paulo, CEP: 01246-902, SP, Brazil.
Vaccine. 2004 Sep 28;22(29-30):3890-6. doi: 10.1016/j.vaccine.2004.04.009.
Pneumococcal protein vaccine based on pneumococcal surface protein A (PspA) is in development with the potential to offer broad range of protection against different strains. We have investigated the frequency of PspA family 1 (Fam1) and family 2 (Fam2) proteins among Streptococcus pneumoniae recovered from ongoing surveillance in Brazil. Fam1 and Fam2 were expressed in comparable rates among 366 isolates, with the potential coverage of 94.3%. PspA families were not associated to age group or source of isolates. However, considering the significant tendency of increasing prevalence of Fam2 associated to widespread dissemination of the genetically-related resistant strains, the monitoring of the PspA families derived from population-based data may be necessary in the context of vaccine development.
基于肺炎球菌表面蛋白A（PspA）的肺炎球菌蛋白疫苗正在研发中，有望对不同菌株提供广泛的保护。我们调查了从巴西正在进行的监测中分离出的肺炎链球菌中PspA家族1（Fam1）和家族2（Fam2）蛋白的频率。在366株分离株中，Fam1和Fam2的表达率相当，潜在覆盖率为94.3%。PspA家族与年龄组或分离株来源无关。然而，考虑到与遗传相关耐药菌株广泛传播相关的Fam2患病率显著增加的趋势，在疫苗研发背景下，基于人群数据监测PspA家族可能是必要的。
