Bifani P, Mathema B, Campo M, Moghazeh S, Nivin B, Shashkina E, Driscoll J, Munsiff S S, Frothingham R, Kreiswirth B N
Public Health Institute Tuberculosis Center, New York, NY 10016, USA.
Emerg Infect Dis. 2001 Sep-Oct;7(5):842-8. doi: 10.3201/eid0705.010512.
A distinct branch of the Mycobacterium tuberculosis W phylogenetic lineage (W14 group) has been identified and characterized by various genotyping techniques. The W14 group comprises three strain variants: W14, W23, and W26, which accounted for 26 clinical isolates from the New York City metropolitan area. The W14 group shares a unique IS6110 hybridizing banding motif as well as distinct polymorphic GC-rich repetitive sequence and variable number tandem repeat patterns. All W14 group members have high levels of streptomycin resistance. When the streptomycin resistance rpsL target gene was sequenced, all members of this strain family had an identical mutation in codon 43. Patients infected with the W14 group were primarily of non- Hispanic black origin (77%); all were US-born. Including HIV positivity, 84% of the patients had at least one known risk factor for tuberculosis.
已通过各种基因分型技术鉴定并表征了结核分枝杆菌W系统发育谱系的一个独特分支（W14组）。W14组包括三个菌株变体：W14、W23和W26，它们占来自纽约市大都市区的26株临床分离株。W14组具有独特的IS6110杂交条带基序以及独特的富含GC的多态性重复序列和可变数目串联重复模式。所有W14组成员都具有高水平的链霉素抗性。对链霉素抗性rpsL靶基因进行测序时，该菌株家族的所有成员在密码子43处都有相同的突变。感染W14组的患者主要是非西班牙裔黑人（77%）；均在美国出生。包括HIV阳性在内，84%的患者至少有一个已知的结核病危险因素。
