从东南亚返回的旅行者中肠炎沙门氏菌血清型对氟喹诺酮类药物敏感性降低。
Reduced fluoroquinolone susceptibility in Salmonella enterica serotypes in travelers returning from Southeast Asia.
作者信息
Hakanen A, Kotilainen P, Huovinen P, Helenius H, Siitonen A
机构信息
Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland.
出版信息
Emerg Infect Dis. 2001 Nov-Dec;7(6):996-1003. doi: 10.3201/eid0706.010613.
Abstract
During 1995 to 1999, we collected 1,210 Salmonella isolates; 629 were from Finnish travelers returning from abroad. These isolates were tested for susceptibility by determining MICs to ciprofloxacin, nalidixic acid, and seven additional antimicrobial agents. From 1995 to 1999, the annual proportion of reduced ciprofloxacin susceptibility (MIC > 0.125 microg/mL) among all travelers' isolates increased from 3.9% to 23.5% (p<0.001). The increasing trend was outstanding among the isolates from Southeast Asia; isolates from Thailand alone increased from 5.6% to 50.0% (p<0.001). The reduced fluoroquinolone susceptibility was nonclonal in character and significantly associated with multidrug resistance. A point mutation in the quinolone resistance-determining region of gyrA was present in all isolates with reduced susceptibility. These data provide further evidence for the rapid spread of multidrug-resistant pathogens from one continent to another.
摘要
1995年至1999年期间，我们收集了1210株沙门氏菌分离株；其中629株来自从国外返回的芬兰旅行者。通过测定对环丙沙星、萘啶酸和其他七种抗菌药物的最低抑菌浓度（MIC）来检测这些分离株的敏感性。1995年至1999年，所有旅行者分离株中环丙沙星敏感性降低（MIC>0.125μg/mL）的年度比例从3.9%增至23.5%（p<0.001）。在来自东南亚的分离株中，这种上升趋势尤为显著；仅来自泰国的分离株就从5.6%增至50.0%（p<0.001）。氟喹诺酮敏感性降低具有非克隆性，且与多重耐药性显著相关。所有敏感性降低的分离株中，gyrA喹诺酮耐药决定区均存在一个点突变。这些数据为多重耐药病原体在各大洲之间的迅速传播提供了进一步证据。
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Clin Microbiol Infect. 1997;3(5):576-577. doi: 10.1111/j.1469-0691.1997.tb00313.x.
2
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Clin Microbiol Infect. 1997;3(5):541-544. doi: 10.1111/j.1469-0691.1997.tb00304.x.
3
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Antimicrob Agents Chemother. 2000 May;44(5):1140-5. doi: 10.1128/AAC.44.5.1140-1145.2000.
4
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10
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J Antimicrob Chemother. 1999 Jan;43(1):145-8. doi: 10.1093/jac/43.1.145.
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